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Close monitoring for evidence of methotrexate toxicity should be done in patients receiving this combination, especially in those with reduced renal function.

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It is created by ehealthme based on reports of 231,270 people who have side effects when taking methotrexate from fda , and is updated regularly.

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Also, simponi received an indication in the eu for use in combination with methotrexate in adults with severe, active and progressive rheumatoid arthritis not previously treated with methotrexate, having been shown to reduce the rate of progression of joint damage as measured by x-ray and to improve physical function.

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When looking at groups of patients on different dmards, the majority of patients continue to take methotrexate after 5 years, far more than other therapies reflecting both its efficacy and tolerability.

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Fenoprofen major in general, nsaid therapy can decrease the clearance of methotrexate, resulting in elevated and prolonged serum methotrexate levels.

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