Your doctor will tell you how often you should take methotrexate.
Methotrexate may reduce the number of clot-forming cells platelets in your blood.
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Noted in patients taking methotrexate to treat arthritis, caffeine may reduce the effectiveness of the drug.
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a systematic review, which included these and some other studies, reported that the use of tetracychnes doxycycline, minocycline, or tetracycline for 3 months or longer was associated with a reduction in disease activity but not in joint damage when compared with placebo or a dmard hydroxychloroquine or methotrexate ; the authors also noted that patients with early onset disease responded better to tetracychnes.
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